منابع مشابه
Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
BACKGROUND Etomidate is a rapidly acting sedative-hypnotic that provides hemodynamic stability. It causes prolonged suppression of adrenocortical steroid synthesis; therefore, its clinical utility and safety are limited. The authors describe the results of studies to define the pharmacology of (R)-3-methoxy-3-oxopropyl1-(1-phenylethyl)-1H-imidazole-5-carboxylate (MOC-etomidate), the first etomi...
متن کاملAdrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate
INTRODUCTION Etomidate is no longer administered as a continuous infusion for anesthetic maintenance or sedation, because it results in profound and persistent suppression of adrenocortical steroid synthesis with potentially lethal consequences in critically ill patients. We hypothesized that rapidly metabolized soft analogues of etomidate could be developed that do not produce persistent adren...
متن کاملClosed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.
BACKGROUND Etomidate is a sedative-hypnotic that is often given as a single intravenous bolus but rarely as an infusion because it suppresses adrenocortical function. Methoxycarbonyl etomidate and (R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate (carboetomidate) are etomidate analogs that do not produce significant adrenocortical suppression when given as a single bolus. However, the effect...
متن کاملEtomidate as an antiarrhythmic.
Editor—We wish to report a case of etomidate reverting ventricular tachycardia to sinus rhythm. Although there have been several case reports and studies demonstrating the antiarrhythmic affects of propofol this has not been true of etomidate. A 59-yr-old man presented to the emergency department with a 2 h history of central chest pain radiating to the left arm and palpitations. He denied any ...
متن کاملEtomidate as an antiarrhythmic
Editor—We wish to report a case of etomidate reverting ventricular tachycardia to sinus rhythm. Although there have been several case reports and studies demonstrating the antiarrhythmic affects of propofol this has not been true of etomidate. A 59-yr-old man presented to the emergency department with a 2 h history of central chest pain radiating to the left arm and palpitations. He denied any ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Anesthesiology
سال: 2009
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181ae63d1